What we do
What we do
The Humphries lab studies cell signaling in tumor recurrence and metastasis. We use our expertise in cell biology and molecular imaging to uncover the mechanisms that contribute to cancer cell heterogeneity, including mitochondrial morphology, cell metabolism, and interactions with the extracellular matrix. Ultimately, we aim to utilize the new information we find out about these processes and transition them into targeted therapies for cancer. Please explore our website for more information.
Co-culture spheroid consisting of cancer cells (green) and fibroblasts (red) (PMC6497540).
Laurdan dye showing single cell differences of membrane order (red=high order) (PMC7275541).
Cells with a mitochondrial fluorescence protein showing enhanced fission (PMC7275541).
Cells with a mitochondrial fluorescence protein showing enhanced fusion (PMC7275541).
Fluorescence lifetime imaging microscopy of a spheroid of only cancer cells (PMC6497540).
Two-photon microscopy of a tumor (cancer cells (green) and collagen (grey) (PMC6497540).
Actin (red) and nuclear (blue) staining of cells (PMC6497540).